Nucleic Acids & Supramolecular Chemistry

The Purse Group at SDSU is a diverse team of graduate and undergraduate researchers using the tools of synthetic and physical organic chemistry to address challenges in the chemical biology of nucleic acids and supramolecular chemistry.

New Paper out: J. Am. Chem. Soc. 2017, 139, 1372–1375.

The Purse Lab has invented a new cytidine analogue that becomes vastly more fluorescent upon incorporation into double-stranded DNA. Remarkably, the fluorescence turn-on response requires correct base pairing with guanosine, allowing visual discrimination of matched sequences, and shown in the photo below (left to right: single stranded probe, matched duplex, mismatched duplex). This fluorescence turn-on response promises new applications in biophysics. Read the details here!