Nucleic Acids & Supramolecular Chemistry

The Purse Group at SDSU is a diverse team of graduate and undergraduate researchers using the tools of synthetic and physical organic chemistry to address challenges in the chemical biology of nucleic acids and supramolecular chemistry.

Research Highlights

Purse Lab paper: J. Am. Chem. Soc. 2017, 139, 1372–1375.

The Purse Lab has invented a new cytidine analogue that becomes vastly more fluorescent upon incorporation into double-stranded DNA. Remarkably, the fluorescence turn-on response is specific to correct base pairing with guanosine, allowing visual discrimination of matched sequences, as shown in the photo below (left to right: single stranded probe, matched duplex, mismatched duplex). This fluorescence turn-on response promises new applications in biophysics. Read the details here!

Purse Lab paper: Chem. Sci. 2017, 8, 7737–7745.

Ultra-talented Purse Lab undergraduates Sara Journey, Kristine Teppang, Cesar Garcia, and Shaylyn Brim have led a study on mechanically induced molecular capsule assembly, showing that their solid state synthesis methods enable the entrapment of guest molecules that cannot be encapsulated using traditional solvent-mediated methods. Congrats to the authors on their important discoveries, which show that there are new opportunities to create organized molecular assemblies entirely in the solid state! Potential applications include drug formulation and materials science. Read the details here!