Fluorescent metabolic labeling of RNA for live-cell imaging

Ani Shalamberidze, a Ph.D. student member of our team, has published a JACS paper in collaboration with the Kleiner Lab at Princeton shows that a combination of judiciously selected fluorescent nucleoside analogues with genetic upregulation of nucleoside kinase activity enables metabolic labeling and live-cell imaging of RNA biology. The method has already been used to discover previously unknown cytoplasmic RNA granules generated during oxidative stress. Great ready for more discoveries in RNA biology!


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