Publications

  1. Wang, D.; Shalamberidze, A.; Arguello, A.E.; Purse, B.W.; Kleiner, R.R. Live-Cell RNA Imaging with Metabolically Incorporated Fluorescent Nucleosides. J. Am. Chem. Soc. 2022, 144, 14647. doi:10.1021/jacs.2c04142
  2. Samaan, G.N.; Wyllie, M.K.; Cizmic, J.M.; Needham, L.-M.; Nobis, D.; Ngo, K.; Andersen, S.; Magennis, S.W.; Lee, S.F.; Purse, B.W. Single-molecule fluorescence detection of a tricyclic nucleoside analogue. Chem Sci 2021, 12, 2623. doi:10.1039/D0SC03903A
  3. Turner, M.B.; Purse, B.W. Fluorescent Tricyclic Cytidine Analogues as Substrates for Retroviral Reverse Transcriptases. ChemPlusChem 2020, 85, 855. doi:10.1002/cplu.202000140
  4. Samaan, G.N.; Paranagama, N.; Haque, A.; Hecht, D.A.; Swairjo, M.A.; Purse, B.W. Structure-based design of guanosine analogue inhibitors targeting GTP cyclohydrolase IB towards a new class of antibiotics. Bioorg. Med. Chem. Lett. 2020, 2, 126818. doi:10.1016/j.bmcl.2019.126818
  5. Bernatchez, J.A.; Coste, M.; Beck, S.; Wells, G.A.; Luna, L.A.; Clark, A.E.; Zhu, Z.; Hecht, D.; Rich, J.N.; Sohl, C.D.; Purse, B.W.; Siqueira-Neto, J.L. Activity of Selected Nucleoside Analogue ProTides against Zika Virus in Human Neural Stem Cells. Viruses 2019, 11, 1365. doi:10.3390/v11040365
  6. Islas, I.J.; Stengel, D.; Garcia, C.A.; Addison, J.B.; Samaan, G.N.; Holland, G.P.; Purse, B.W. 2H NMR reveals liquid state-like dynamics of arene guests inside hexameric pyrogallol[4]arene capsules in the solid state. Org. Chem. Front. 2019, 6, 1361-1366. doi:10.1039/C9QO00232D
  7. Teppang, K.L.; Lee, R.W.; Turner, M.B.; Lokensgard, M.E.; Cooksy, A.L.; Purse, B.W. Electronic modifications of fluorescent cytidine analogues control photophysics and fluorescent responses to base stacking and pairing. Chem. Eur. J. 2019, 25, 1249-1259. doi:10.1002/chem.201803653
  8. Turner, M.B.; Anderson, B.A.; Samaan, G.N.; Coste, M.; Burns, D.D.; Purse, B.W. Synthesis of Fluorescence Turn‐On DNA Hybridization Probe Using the DEAtC 2′‐Deoxycytidine Analog Curr. Protoc. Nucleic Acid Chem. 2018, 75, e59. doi:10.1002/cpnc.59
  9. Bernatchez, J.A.; Yang, Y.; Coste, M.; Li, J.; Beck, S.; Liu, Y.; Clark, A.E.; Zhu, Z.; Luna, L.A.; Sohl, C.; Purse, B.W.; Li, R.; Siqueira-Neto, J.L. Development and validation of a phenotypic high-content imaging assay for assessing the antiviral activity of small-molecule inhibitors targeting the Zika virus. Antimicrob. Agents Chemother. 2018, 62, e00725-18. doi:10.1128/AAC.00725-18
  10. Journey, S.N.; Teppang, K.L.; Garcia, C.A.; Brim, S.A.; Onofrei, D.; Addison, J.B.; Holland, G.P.; Purse, B.W. Mechanically induced pyrogallol[4]arene hexamer assembly in the solid state extends the scope of molecular encapsulation. Chem. Sci. 2017, 8, 7737-7745. doi:10.1039/C7SC03821F
  11. Burns, D.D.; Teppang, K.L.; Lee, R.W.; Lokensgard, M.E.; Purse, B.W. Fluorescence Turn-On Sensing of DNA Duplex Formation by a Tricyclic Cytidine Analogue. J. Am. Chem. Soc. 2017, 139, 1372-1375. doi:10.1021/jacs.6b10410
  12. Chapin, J.C.; Purse, B.W. cis,cis-1,3,5-Trimethyl-1,3,5-cyclohexanetricarboxylic acid (Kemp’s Triacid). Encyclopedia of Reagents for Organic Synthesis, 2015. doi:10.1002/047084289X.rn01749
  13. Mehdizadeh, E.; Chapin, J.C.; Gonzales, J.M.; Rahafrooz, A.; Abdolvand, R.; Purse, B.W.; Pourkamali, S. Microelectromechanical disk resonators for direct detection of liquid-phase analytes. Sensor Actuat. A–Phys. 2014, 216, 136–141. doi:10.1016/j.sna.2014.05.022
  14. Chapin, J.C.; Purse, B.W. Guest loading, chromatographic purification, and controlled release from kinetically trapped, hydrogen-bonded pyrogallol[4]arene capsules. Supramol. Chem. 2014, 7–8, 517–520. doi:10.1080/10610278.2013.863314
  15. Rodgers, B.J.; Elsharif, N.A.; Vashisht, N.; Mingus, M.M.; Mulvahill, M.A.; Stengel, G.; Kuchta, R.D.; Purse, B.W. Functionalized Tricyclic Cytosine Analogues Provide Nucleoside Fluorophores with Improved Photophysical Properties and a Range of Solvent Sensitivities. Chem. Eur. J. 2014, 20, 2010–2015. doi:10.1002/chem.201303410
  16. Chapin, J.C.; Kvasnica, M.; Purse, B.W. Molecular Encapsulation in Pyrogallolarene Hexamers Under Nonequilibrium Conditions. J. Am. Chem. Soc. 2012, 134, 15000. doi:10.1021/ja305252t
  17. Stengel, G.; Purse, B.W.; Kuchta, R.D. Effect of transition metal ions on the fluorescence and Taq-catalyzed polymerase chain reaction of tricyclic cytidine anologues. Anal. Biochem. 2011, 416, 53-60. doi:10.1016/j.ab.2011.04.033
  18. Kvasnica, M.; Chapin, J.C.; Purse, B.W. Efficient Loading and Kinetic Trapping of Hexameric Pyrogallolarene Capsules in Solution. Angew. Chem. Int. Ed. 2011, 50, 2244-2248. doi:10.1002/anie.201007800
  19. Kvasnica, M.; Purse, B.W. Specific Tetramethylammonium Recognition Drives General Anion Positioning in Tandem Sites of a Deep Cavitand.New J. Chem. 2010, 34, 1097-1099. doi:10.1039/C0NJ00224K
  20. Stengel, G.; Urban, M.; Purse, B.W.; Hocek, M.; Kuchta, R.D. Incorporation of the fluorescent nucleotide analogue tCTP by T7 RNA polymerase. Anal. Chem. 2010, 82, 1082-1089. doi:10.1016/10.1021/ac902456n
  21. Urban, M.; Joubert, N.; Purse, B.W.; Hocek, M.; Kuchta, R.D. Mechanisms by Which Human DNA Primase Chooses to Polymerize a Nucleoside Triphosphate. Biochemistry 2010, 49, 727-735.
  22. Stengel, G.; Urban, M.; Purse, B.W.; Kuchta, R.D. High density labeling of PCR products with the fluorescent analogue tCo. Anal. Chem. 2009, 81, 9079-9085.
  23. Stengel, G.; Purse, B.W.; Wilhelmsson, L.M.; Urban, M.; Kuchta, R.D. Ambivalent incorporation of the fluorescent cytosine analogues tC and tCo by human DNA polymerase α and Klenow Fragment. Biochemistry2009, 48, 7547-7555.
  24. Purse, B.W.; Butterfield, S.M.; Ballester, P.; Shivanyuk, A.; Rebek, J., Jr. Interaction Energies and Dynamics of Acid–Base Pairs Isolated in Cavitands. J. Org. Chem, 2008, 73, 6480-6488.
  25. Johansson, M.; Purse, B.W.; Terasaki, O.; Bäckvall, J.-E. Aerobic oxidations catalyzed by a zeolite-encapsulated cobalt salophen complex. Adv. Synth. Catal., 2008, 350, 1807-1815.
  26. Purse, B.W.; Tran, L.-H.; Piera, J.; Åkermark, B,; Bäckvall, J.-E. Synthesis of New Hybrid Hydroquinone-Cobalt Schiff Base Catalysts: Efficient Electron Transfer Mediators in Aerobic Oxidations. Chem. Eur. J., 2008, 14, 7500-7503.
  27. Purse, B.W.; Rebek, J., Jr. Self-Fulfilling Cavitands: Packing Alkyl Chains into Small Spaces. Proc. Natl. Acad. Sci. USA, 2006, 103, 2530-2534.
  28. Purse, B.W.; Gissot, A.; Rebek, J., Jr. A Deep Cavitand Provides a Structured Environment for the Menschutkin Reaction. J. Am. Chem. Soc., 2005, 127, 11222-11223.
  29. Purse, B.W.; Rebek, J., Jr. Functional cavitands: Chemical reactivity in structured environments. Proc. Natl. Acad. Sci. USA, 2005, 102, 10777-10782.
  30. Purse, B.W.; Rebek, J., Jr. Encapsulation of oligoethylene gylcols and perfluoro-n-alkanes in a cylindrical host molecule. Chem. Commun., 2005, 722-724.
  31. Purse, B.W.; Ballester, P., Rebek, J., Jr. Reactivity and molecular recognition: amine methylation by an introverted ester. J. Am. Chem. Soc., 2003, 125, 14682-14683.
  32. Purse, B.W.; Shivanyuk, A.; Rebek, J., Jr. Resorcin[6]arene as a building block for tubular crystalline architectures. Chem. Commun., 2002, 2612-2613.
  33. Nitz, M.; Purse, B.W.; Bundle, D.R. Synthesis of a β1,2-mannopyranosyl tetrasaccharide found in the phosphomannan antigen of Candida albicans. Org. Lett., 2000, 2, 2939-2942.