Congratulations to Ben Turner on his new paper that’s just out in ChemPlusChem! Ben’s results show that fluorescent tricyclic cytidine analogues tC and DEAtC are substrates for retroviral reverse transcriptases. They can be used by these enzymes to synthesize fluorescently labeled double-stranded DNA from an RNA template. Further development of Ben’s methods may lead to ways to monitor the replication of retroviruses such as HIV in cell or tissue culture. Read Ben’s article here!
