The Purse Lab has a new paper out in Chemistry—A European Journal. Lead authors Kristine Teppang, Ray Lee, and Dillon Burns, along with Ben Turner, Melissa Lokensgard, and collaborator Andy Cooksy have studied how base pair and stacking changes the fluorescence of a series of nucleoside analogues. Their findings include striking correlations between the electronic nature of the analogues and their neighboring bases in duplex DNA. We expect that this work, plus further studies by us and others, will eventually lead to the ability to predict fluorescent properties of such molecular probes before synthesizing and testing them. Read the details here.
