Fluorescent metabolic labeling of RNA for live-cell imaging

Ani Shalamberidze, a Ph.D. student member of our team, has published a JACS paper in collaboration with the Kleiner Lab at Princeton shows that a combination of judiciously selected fluorescent nucleoside analogues with genetic upregulation of nucleoside kinase activity enables metabolic labeling and live-cell imaging of RNA biology. The method has already been used to discover previously unknown cytoplasmic RNA granules generated during oxidative stress. Great ready for more discoveries in RNA biology!

https://doi.org/10.1021/jacs.2c04142

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