Category Archives: Uncategorized

Congrats to George Samaan for his first authorship of our new publication, Single-molecule fluorescence detection of a tricyclic nucleoside analogue, just out in Chemical Science! Along with undergrads Mckenzie Wyllie and Julian Cizmic, George created this molecule, informed in part … Continue reading →

ChemistryViews, the online magazine of Chemistry Europe, has just published a highlight of Ben Turner’s new research article describing the use of fluorescent nucleotide substrate analogues for retroviral reverse transcriptases! Check out their coverage of Ben’s research! <http://www.chemistryviews.org/details/ezine/11242991/Reverse_Transcription_Used_to_Generate_Fluorescent_DNA.html>

Dana Rosansky is joining the Purse Lab, fresh after finishing her B.A. in Biochemistry from the University of San Diego. Dana worked with Prof. Tammy Dwyer at USD on NMR studies on the structure of chemically modified DNA. Now she’s … Continue reading →

Congratulations to Ben Turner on his new paper that’s just out in ChemPlusChem! Ben’s results show that fluorescent tricyclic cytidine analogues tC and DEAtC are substrates for retroviral reverse transcriptases. They can be used by these enzymes to synthesize fluorescently … Continue reading →

Congratulations to George Samaan for his 1st first-author paper, just published in Bioorg. Med. Chem. Lett.! Our new study shows that structure-guided inhibitor design can be used to prepare new 8-oxo-G analogues as GTP cyclohydrolase inhibitors with the potential to … Continue reading →

Today we published a new paper on our efforts to combat the Zika virus. Lead authors Jean Bernatchez of UCSD and Michael Coste (from the Purse Lab at SDSU) have shown that the activity of Zika inhibitors synthesized by Michael … Continue reading →

Congratulations to Irazema, Dillan, Cesar, Bennett, and George for a great new paper out on supramolecular mechanochemistry. Our results show that the guest molecules in molecular capsules assembled in the solid state tumble in a liquid-like fashion within the confines … Continue reading →

October 18, 2018 Two papers from the Purse Lab appeared online on this day. It’s the first time in the history of our lab that we have had two papers published on the same day. They’re publications number 26 and … Continue reading →

The Purse Lab has a new paper out in Chemistry—A European Journal. Lead authors Kristine Teppang, Ray Lee, and Dillon Burns, along with Ben Turner, Melissa Lokensgard, and collaborator Andy Cooksy have studied how base pair and stacking changes the fluorescence … Continue reading →

Purse Lab PhD student Michael Coste is working with our collaborators in the Sohl Lab (SDSU) and Siqueira-Neto Lab (UCSD) to develop new inhibitors of Zika virus replication. Our first publication on this project is now available online at Antimicrobial … Continue reading →